092 Interstitial expansion in health and disease—an equilibrium contrast CMR study
نویسندگان
چکیده
منابع مشابه
Interstitial expansion in health and disease - an equilibrium contrast CMR study
Methods The three steps in EQ-CMR are: 1) a primed gadolinium infusion to achieve contrast equilibrium, 2) Signal (T1) measurement pre and post equilibrium, 3) measurement of blood contrast volume (1haematocrit). This allows calculation of Vd(m) by: Vd(m) =(1-hematocrit) x Δ(1/T1)myo ÷ Δ(1/T1)blood. Vd(m) was measured in 278 subjects: 86 normal subjects (median age 43, range 24 to 81, 51% male)...
متن کاملAssessment of the interstitial volume in healthy volunteers. An equilibrium contrast CMR study
Methods 86 healthy subjects (median age 45, range 24-81, 42 males) were recruited from hospital, university or via a local General Practitioner surgery. All were assessed with a cardiac history and examination, routine blood tests, 12 lead ECG, blood pressure and clinical CMR. Volunteers were excluded if any evidence of cardiovascular disease was found. Baseline differences between male and fem...
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Background Systematic amyloidosis is a severe, diagnostically challenging, disorder characterised by the extracellular deposition of insoluble abnormal protein fibrils [1]. Recently, Flett et al [2] showed that the volume of distribution of gadolinium (Gd) contrast agents, calculated by EQ-CMR, can be used to measure fibrosis. This technique uses the extracellular nature of Gd to relate the vol...
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Methods Using international diagnostic guidelines we identified 28 patients with fDCM (mean age 42, 61% male, 89% NYHA class I, 11% NYHA class II). This cohort excluded the most severe cases of fDCM due to the high prevalence of permanent pacemakers or ICDs. The Vd(m) (a measure of DMF) was compared to that obtained in healthy volunteers (mean age 35, 63% male) and also to other indexed CMR par...
متن کاملBeyond late gadolinium enhancement: the key role of diffuse myocardial fibrosis in severe aortic stenosis - an Equilibrium Contrast CMR study
Background In severe aortic stenosis (AS), hemodynamics and conventional indices do not fully explain symptoms, prognosis or treatment response. We hypothesize that diffuse myocardial fibrosis (DMF) is a key missing factor in AS. This can now be accurately measured non-invasively using equilibrium contrast CMR (EQ-CMR) [1] involving a primed gadolinium infusion, T1 measurement preand post-infus...
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ژورنال
عنوان ژورنال: Heart
سال: 2012
ISSN: 1355-6037,1468-201X
DOI: 10.1136/heartjnl-2012-301877b.92